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Roche Switzerland bridges the gap between pharmaceuticals and diagnostics. Important research and development functions are located here. For our long-term client, F. Hoffmann-La Roche AG in Basel, we are looking for a

Background:

In the Immunology group, the team is developing cutting edge therapies to treat rare blood disorders. As a member of Immunology, you will be part of a highly collaborative, international group of research associates and scientists that are developing medicines for the future. This team is currently looking for a research associate to assess efficacy, safety and translatability of gene therapies in rare blood disorders (bleeding/thrombotic disorders, anemia, etc..) by using different in vivo and ex vivo assays. Together with a larger team you will work with preclinical animal models and human patient material (blood and plasma) and characterize different gene therapy assets in hemostasis and thrombosis. The ex vivo and in vivo approaches will require you to be skilled in end-to-end experiments from the hands-on animal study, sample collection to different ex vivo assays.

These responsibilities capture a portion of what your work will look like:

• Executing diverse in vivo experiments (i.v. injections, blood and plasma collection, bleeding and thrombosis models or similar) and managing necessary animal welfare requirements (LTK1)
• Characterizing efficacy and safety of novel gene therapy assets using molecular and biochemical techniques (ELISA, Thrombin generation assay, chromogenic assays, etc) in murine and human samples
• Preparation, handling and in vitro/ex vivo testing and analysis of patient-derived material, including blood and plasma
• Collaborating on the development of new experimental strategies and custom assays with our research scientists
• General lab management and organization, incl. maintenance, safety, inventory, etc.
• Contributing to data analysis and communicating results to the team
• Taking and maintaining detailed documentation of data

Must Haves:

• MSc/BSc in Life Sciences (cellular/ molecular biology, pharmacology, immunology), or completion of an apprenticeship for a research associate (“Lehrabschluss”) with ? 3 years of academic or industry experience
• Allowance to conduct animal experimentation (active LTK1, FELASA or equivalent) and experience with rodents is necessary, including intravenous injections and blood collection is required, surgery experience is a plus
• Extensive mouse work experience
• High motivation, flexibility, and excellent organizational skills to support our team 
• You can communicate fluently in English
• Open and collaborative spirit
• Vigorous “can do” mentality to succeed in a dynamic and highly collaborative research team

Nice to Have:

• Hands-on experience in molecular (protein-based) and biochemical assays
• Background in coagulation

What you will be offered:

• An opportunity to work in one of the world's most important pharmaceutical companies
• Modern campus with plenty of green spaces and meeting areas
• Central location in Basel
• Varied job profile
• Further training opportunities through temptraining
• Working in a dynamic and motivated team

If you are interested please send your application documents addressed to Ms Marica Hug.

Basel-Stadt Research Associate in vivo gene therapy in Rare Blood Disorders Scientific Associate Labor Laboratory