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UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

The Department of Fundamental Microbiology (https://www.unil.ch/dmf) offers a position of Doctoral Student SNSF focused on transcription dynamics induced by MAPKs. The position is embedded within the quantitative signaling research group of Dr. Serge Pelet (https://wp.unil.ch/quantitativesignaling).

Expected start date : 01.02.2025

Contract length : 1 year, renewable for maximum 4 years

Activity rate : 100%

Workplace : University of Lausanne, Dorigny campus.

The aim of the project is to study the dynamics of transcription stimulated by MAPK pathways in the model organism Saccharomyces cerevisiae.

In all eukaryotic cells, MAPK cascades relay extracellular information into a defined biological response, which encompasses the induction of a specific transcriptional program. We have established several live-cell microscopy assays to monitor the dynamics of transcription upon activation of a MAPK pathway in budding yeast. The objective of this project is to apply these tools to understand the role of the promoter sequences in defining the characteristics of the transcription dynamics. In addition, optogenetics will be used to control the localization of the MAPK in the nucleus and single molecule imaging techniques will be implemented to get deeper insights into the binding of transcription factors on DNA.

The project will combine wet lab experiments, microscopy measurements and image analysis and will provide an excellent scientific training with opportunities for collaborations in a stimulating environment.

The successful candidate should hold a Master degree in Biology or equivalent, prior experience in yeast biology, signal transduction or fluorescence microscopy is an asset. Candidates without wet lab affinity will not be considered. A good command of the English language, a high personal motivation to excel in science and a curious mind are required.

We offer a stimulating environment in an international research group. We are part of a multicultural, diversified and dynamic academic environment, with opportunities for professional training. See the lab website (https://wp.unil.ch/quantitativesignaling) for information on our publications and current research.

Dr Serge Pelet

Email: Write an email

Deadline : 01.12.2024

Please include your full application (motivation letter, CV with detailed classes and grades, list of publications or presentations, and the contact details of two referees) in a PDF.

Only applications through this website will be taken into account, we thank you for your understanding.

UNIL is committed to:

•    equality, diversity and inclusion within its community;

•    ensuring an open and respectful environment that is conducive to personal development;

•    offering working conditions that facilitate work-life balance;

•    supporting early career researchers.

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