Scientist / Senior Scientist
Scientist / Senior Scientist
100%, Zurich, fixed-term
The Wyss Zurich Translational Center is a joint accelerator of the ETH Zurich and the University of Zurich, which was made possible by a generous donation from the Swiss entrepreneur and philanthropist Dr. hc. mult. Hansjörg Wyss. The mission of Wyss Zurich is to drive the clinical translation and technology transfer of outstanding scientific discoveries into new therapies for patients and breakthrough innovations in the emerging fields of Regenerative Medicine and Robotics, and to promote hybrid technologies in these fields. Wyss Zurich brings together some of the world’s leading experts to form multidisciplinary teams, pooling their knowledge and expertise. For further information: https://www.wysszurich.ch/projects/tandem
Project background
Project Tandem is developing peptide-based therapeutics to target and treat fibrosis to potentially repair and regenerate normal organ function. The extracellular matrix targeting platform and assets stem from emerging concepts of mechanobiology and its role in driving disease progression.
The position will be lab-based at the Bio Technopark Schlieren with potential for supervisory duties. You are a self-motivated scientist with demonstrated communication and organizational skills who can work collaboratively in a dynamic environment.
Job description
Roles & Responsibilities
- Lead in vitro assay development
- Identify and investigate PD biomarkers relavent to disease and drug intervention
- Develop & design experiments and research plans to elucidate therapeutic mechanism of action
- Conduct and troubleshoot a wide range of biological/molecular/biochemical assays including, but not limited to: FACS, ELISAs, , RT-PCR, Western blotting, co-IPs
- Manage/participate in CRO relationships
- Mentoring of junior colleagues
- Document, analyze, interpret and present experimental data in a clear and concise manner, contributing to data room and investor presentations
- Independently research new technologies and approaches to apply to the drug discovery and development pipeline
- Present in high level conferences, draft and submit manuscripts, contribute to grant writing
In daily practice…..
- Setting up the lab and best practices
- Plan and Design experiments coordinating with clear milestones on the project
- Perform validation assays and preclinical experiments
- Perform data analysis and prepare and present reports
- Drive CRO interaction and vendor management for preclinical studies
- Organize laboratory, develop SOPs, maintain equipment, order supplies, maintain detailed records of laboratory experiments, and other duties as required
Profile
Required Qualifications
- PhD with 3-8 years of recent lab-based biotech/pharma industry experience
- Experience with human (and mouse) biomarkers
- Experience with protein assay platforms (ELISA, Luminex, MSD, etc.)
- Experience with flow cytometry methods and interpretation (immunophenotyping, cell markers)
- Experience and ability to plan and execute molecular, cellular and biochemical techniques in 96/384 well format
- Able to take direction but also work independently and troubleshoot
- Demonstrates attention to detail and record keeping
- Team player: understands and appreciates working towards common goals in start-up environment and in a small team
- Flexibility to adapt workplans to rapidly changing priorities and deadlines
- Candidates must possess a valid work permit in Switzerland
Preferred Qualifications
- Background in fibrosis, immunology/inflammation, cytokines, growth factors, extracellular matrix biology
- Knowledge/experience working with biotherapeutics, mix modalities
- Experience with phenotypic assay development (flow cytometry and microscopy)
- Experience in high throughput screening such as by phenotype, microscopy, ELISA
- Experience with IHC
Workplace
Workplace
We offer
- Company mission that aims to impact the lives of patients with life threatening conditions with a novel & innovative approach
- An opportunity to work in the exciting field of mechno-medicine and its broad implications in fibrosis & oncology
- Fast-paced, highly stimulating environment with a collaborative atmosphere
- Unique opportunity to join a company at an early stage, with avenues for career development
- Competitive salary, with additional advantages and incentives including a fully-funded pension
- Respectful and equal opportunity work environment, in a world-class location
TANDEM strives to build a diverse team, and particularly encourages women and other groups underrepresented in the Biotech/Bioengineering field to apply. Submit your detailed CV and a motivation letter for this position by August 10, 2024. Interviews will be scheduled on a rolling basis.
We value diversity
Curious? So are we.
We look forward to receiving your online application with the following documents:
- Motivation letter
- CV
- Diplomas and reference letters
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Questions regarding the position should be directed to Dr. Mamta Chabria, email Write an email (no applications).
For recruitment services the GTC of ETH Zurich apply.
About ETH Zürich
Curious? So are we.
We look forward to receiving your online application with the following documents:
- Motivation letter
- CV
- Diplomas and reference letters
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Questions regarding the position should be directed to Dr. Mamta Chabria, email Write an email (no applications).
For recruitment services the GTC of ETH Zurich apply.
