Research Assistant /Associate - DMPK (100%, m/f/d)

NBE-Therapeutics is a subsidiary of the Boehringer Ingelheim group: a perfect symbiosis between a rapidly growing biotechnology company and an already well-established big pharma. We are located in Basel, a Swiss city on the river Rhine, known for being an important center of chemical and pharmaceutical industries and renowned for its versatile cultural aspects – a great place to live and work. Our research team is committed to the development of next generation antibody drug conjugates (ADCs) for cancer patients in need for new transformational treatments.

In our Preclinical Pharmacokinetics and Drug Metabolism Department, we are seeking a talented Research Assistant /Associate – (100%, m/f/d) for our laboratory dealing with the characterization of new ADC drug candidates.

Job Description

Provide technical support to preclinical research currently ongoing at NBE-Therapeutics. You will be involved in

• development of screening assays to identify ADC/ payload weaknesses in early stages
• provide ad hoc support for DMPK specific questions (e.g., catabolism, metabolism, MetID)
• grant access to discovery assays that allow prediction of ADC behavior in vivo (e.g., blood stability)
• assay development for EIH enabling studies (e.g., DDI potential) and beyond

Your Profile

• Technical diploma, B.Sc. or M.Sc. in chemistry, pharmacology, biology, or other relevant science disciplines. The position is not suitable for candidates holding a PhD, thus their application will not be considered.
• Strong experimental background in development of biochemical assays
• Profound experience with HPLC coupled to mass spectrometry
• At least 5+ years’ experience with LC-MS analytic
• Experience with performing biochemical assays
• Basic knowledge in cell culturing (biological safety level 2)
• Good communication and organizational skills and the ability to work in a team
• Good command of English

Your Tasks and Responsibilities

• Development of analytical methods for the generation of mass spectrometry profiles from in vitro and in vivo studies performed with ADCs or payloads (small molecules)
• Development of biochemical assays in order to characterize ADCs and its payloads
• Generation of in vitro metabolic profiles in subcellular fractions and cell culture
• Preliminary metabolite structure identification of payloads
• Ability to efficiently plan, organize and clearly document experimental work in a multidisciplinary environment

What NBE-Therapeutics AG offers

• Exciting opportunities for development and professional growth within our dynamic organization
• A collaborative and solution-oriented environment where you can make a difference
• An opportunity to make a difference in future cancer therapies and save patients’ lives
• An innovative and open culture in a multicultural environment
• A competitive salary and generous social benefits
• The position will be available as of 01.10.2024

Who We Are and Our Culture

NBE-Therapeutics is an equal opportunity employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment, which benefits our employees, patients and communities.

In January 2021, NBE-Therapeutics joined as a subsidiary specialized in ADCs, the Boehringer Ingelheim group, which focuses on innovative medicines for people and animals since more than 130 years. Boehringer Ingelheim is one of the pharmaceutical industry’s top 20 companies and to this day remains family-owned. Day by day, more than 53’000 employees create value through innovation for the three business areas human pharmaceuticals, animal health and biopharmaceutical contract manufacturing. In 2023, Boehringer Ingelheim achieved a total revenue of nearly 25.6 billion euros. R&D investments, exceeding 5.8 billion euros, corresponded to 22.5% of net sales.

We look forward to receiving your application, including a motivation letter.

Please, send your documents to Write an email referring to job-opening: Ref240712.