Characterization of INPHORS, a novel signaling pathway in phosphate and energy homeostasis

UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

A postdoctoral position is available in the laboratory of Prof. Andreas Mayer in the Department of Immunobiology, University of Lausanne, Switzerland.

Expected start date in position: to be agreed

Contract length: 1 year, renewable 2 x 2 years, maximum 5 years

Activity rate: 100%

Workplace: Department of Immunobiology

Cells control their cytosolic concentration of inorganic phosphate, which is both an essential nutrient and potentially toxic, because they face a phosphate challenge. On the one hand, growth requires a minimal concentration of this limiting resource because intracellular inorganic phosphate (Pi) is a compound of nucleic acids and phospholipids and modifies most cellular proteins. At the same time, cytosolic Pi may not rise much, because elevated cytosolic Pi can stall metabolism. It reduces the free energy that nucleotide triphosphate hydrolysis can provide to drive energetically unfavorable reactions. Our group elucidates how cells strike this critical balance. We use yeast and mammalian cells to characterize a novel signaling pathway for intracellular phosphate management (INPHORS), which employs several evolutionarily conserved elements: SPX domains, inositol pyrophosphates, which are their ligands, and inorganic polyphosphates. We seek to reinforce our team with a highly motivated collaborator to explore this fundamental signaling and homeostasis pathway and its role in health and disease.

Candidates with a PhD, experience and a thorough training in biochemistry, chemistry, molecular or cell biology are particularly encouraged to apply. Knowledge of yeast genetics and advanced cellular imaging techniques is advantageous but not essential.

We offer a stimulating working atmosphere in a multicultural, diverse and dynamic academic environment, opportunities for professional training and numerous other benefits to discover.

Prof. Andreas Mayer

University of Lausanne

Department of Immunobiology

1066 Epalinges Switzerland

Write an email

Deadline : 30.09.2024

Applications should contain a cv, a description of your previous work, a brief statement of your research interests and objectives, and contact information of two or more referees. Please, send your full application in Word or PDF.

Only applications through this website will be taken into account

We thank you for your understanding.

UNIL is committed to equal opportunities and diversity.
www.unil.ch/egalite

UNIL supports early career researchers.
www.unil.ch/graduatecampus